Phyu, Mya Pwint Hlain, Zarchi Theint Theint Zaw, Thurein Htway, Soe Minn Sein, Mya Thanda text monographic eng

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Objective. This study determined the correlation between erythrocyte acetylcholinesterase (AChE) activity, serum malondialdehyde (MDA) and insulin sensitivity in agricultural workers and non-agricultural workers. Methodology. The cross-sectional comparative study was undertaken in 45 agricultural and 45 non-agricultural workers from Nat-Kan Village, Magway Township. Erythrocyte acetylcholinesterase activity and serum malondialdehyde were measured by spectrophotometric method. Insulin sensitivity was calculated by homeostasis model assessment (HOMA-IR). Results. Mean erythrocyte AChE activity was significantly lower in agricultural (3553.99 IU/L) compared with nonagricultural workers (4432.68 IU/L) (p<0.001). A significant high level of mean serum MDA was observed in agricultural workers (0.74 versus 0.28 μmol/L, p<0.001). Median HOMA-IR value was significantly higher in agricultural (2.74) than that of non-agricultural workers (2.28) (p<0.05). The risk of insulin resistance was 2.8 times greater in agricultural workers than non-agricultural workers (OR 2.8, 95% CI, 1.18 to 6.72). Erythrocyte AChE activity had weak negative correlation with serum MDA level (r=-0.357, p<0.001) and HOMA-IR (ρ= 0.305, p<0.05). There was a significant but weak positive correlation between serum MDA level and HOMA-IR (ρ=0.355, p<0.001). Conclusion. Organophosphate pesticide exposure lowered erythrocyte AChE activity and increased oxidative stress. Oxidative stress is partly attributed to the development of insulin resistance. Mya Pwint Phyu [and four others] In: Journal of the ASEAN Federation of Endocrine Societies, 2020 Vol. 35 (1) pages: 85-92 https://asean-endocrinejournal.org/index.php/JAFES/article/view/645/1289 https://asean-endocrinejournal.org/index.php/JAFES/article/view/645/1289 201127 20201127105647.0 D0001E000158