TY  - BOOK
AU  - Li,Hongying
AU  - Mendelsohn,Emma
AU  - Zong,Chen
AU  - Zhang,Wei
AU  - Hagan,Emily
AU  - Wang,Ning
AU  - Li,Shiyue
AU  - Yan,Hong
AU  - Huang,Huimin
AU  - Ross,Noam
AU  - Chmura,Aleksei
AU  - Gerry,Philip
AU  - Fielder,Mark
AU  - Miller,Maureen
AU  - Shi,Zhengli
AU  - Daszak,Peter
TI  - Human-animal interactions and bat coronavirus spillover potential rural residents in Southern China
PY  - 2019///
PB  - Elsevier
KW  - Coronavirus
KW  - Host Microbial Interactions
KW  - Chiroptera
KW  - Bats
KW  - COVID-19
KW  - Virus Host Interactions
N1  - From the journal: Biosafety and Health 1 (2019) 84-90; Includes bibliographic references
N2  - Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and the link between specific interactions and spillover risk is poorly understood. To investigate this phenomenon, we conducted biological-behavioral surveillance among rural residents in Yunnan, Guangxi, and Guangdong districts of Southern China, where we have identified a number of SARS-related coronaviruses in bats. Serum samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays (ELISA). Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk. A total of 1,596 residents were enrolled in the study from 2015 to 2017. Nine participants (0.6%) tested positive for bat coronaviruses. 265 (17%) participants reported severe acute respiratory infections (SARI) and/or influenza-like illness (ILI) symptoms in the past year, which were associated with poultry, carnivore, rodent/shrew, or bat contact, with variability by family income and district of residence. This study provides serological evidence of bat coronavirus spillover in rural communities in Southern China. The low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare event. Nonetheless, this study highlights associations between human-animal interaction and zoonotic spillover risk. These findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence
UR  - https://www.sciencedirect.com/science/article/pii/S2590053619300308
ER  -