02381nam a22001937a 4500003000400000005001700004008004100021245020500062520160900267580005501876650002501931650001101956650003101967700002201998700002102020942000702041999001502048952012402063DOH20210312101541.0210312b           ||||| |||| 00| 0 eng d00aValue of post-therapy whole body scintigraphy in predicting the need for subsequent radioactive iodine therapy in patients with well-differentiated thyroid carcinoma /cJerry M. Obaldo, Ruben V. Ogbac3 aINTRODUCTION: Patients with well-differentiated thyroid carcinoma (WDTC) may require more than one session of radioactive iodine therapy (RAIT). This study was conducted to determine if post-therapy whole body scintigraphy (PTWBS) can identify patients who will require repeat RAIT due to persistent disease.

METHOD: The records of patients with WDTC who were referred to the Philippine General Hospital for RAIT from 2005-2007 were reviewed in this retrospective cohort study. PTWBS results (number of remnants, area of remnants, and presence of metastasis) of patients who had repeat RAIT (based on laboratory and clinical evidence of persistent disease) were compared with those of patients who did not have repeat RAIT. Multiple logistic regression analysis was done.

RESULTS: Forty-five of 99 patients in the study [45%, 95% Confidence Interval (CI): 35 had repeat RAIT. Thirty-six of 38 patients (95%) with metastases on PTWBS required repeat RAIT, while only 9 of 61 patients (15%) with no scan evidence of metastases required subsequent therapy. Controlling for age group (age), the odds ratio was 102 (95% CI: 20 . Positive and negative predictive values were 95 and 85% respectively. The same results were obtained using metastases alone as a predictor. Twenty-six patients had extra-cervical metastases by PTWBS and all required repeat RAIT. The number and aggregate size of thyroid remnants by PTWBS, however, were not found to be predictive of the need for repeat therapy.

CONCLUSION: The presence of functioning metastases seen on PTWBS was highly predictive of the need for repeat RAIT.  aActa Medica Philippina, 2009 43 ( 4 ) pages 69-75  2aRadionuclide Imaging 2aIodine 2aThyroid Neoplasmsxtherapy1 aObaldo, Jerry M. 1 aOgbac, Ruben V.   cJA  c3452d3452  00102nlm4070aDOHCLbDOHCLcElectronicResd2021-03-12l0oJ000138pD0001J000138r2021-03-12 00:00:00w2021-03-12yJA