01502nam a22001697a 4500001001300000003000400013005001700017008004100034100002300075245017100098520088600269580005601155650003901211650003801250650003101288650001301319D0001J000159DOH20210312143258.0210312b           ||||| |||| 00| 0 eng d1 aMontoya, Jaime C. 00aDiagnosis of tuberculous meningitis using enzyme-linked immunosorbent assay utilizing a 30,000-dalton native antigen of mycobacterium tuberculosis /cJaime C. Montoya3 aAn enzyme-linked immunosorbent assay (ELISA) was estimated for the detection of lgG antibody in human cerebrospinal fluid (CSF) from patients with tuberculous meningitis to the 30,000-Da native antigen of Mycobacterium tuberculosis. The test was done on patients with bacteriologically confirmed and autopsy-proven tuberculous meningitis (8 cases), clinically presumptive cases of tuberculous neurologic disease (88 cases) and normal patients with neurologic disease (10 cases). The test was positive in 7 of the 8 cases of bacteriologically confirmed tuberculous meningitis (87.5%). ELISA was also positive in 67 of 100 cases of clinically presumptive tuberculous meningitis (67.00%). Overall sensitivity was found to be 68.51%. Specificity of ELISA was found to be 97.95% (96/98). The results show the potential use of ELISA as a rapid diagnosis test for tuberculous meningitis .  aActa Medica Philippina, 2000 36 ( 1&2 ) pages 22-26 2aTuberculosis, Meningealxdiagnosis 2aEnzyme-Linked Immunosorbent Assay 2aMycobacterium tuberculosis 2aAntigens