Ocampo, Cherie C. Tenoso, Marso D. Bautista, Ma.Rhida M. Melendres, Jose Roberto Q. Tomas, Juliet M. Sto. Balgos, Abundio Magommang, Mayshara M. Salvosa, Farlah Angela M. Zalameda, Carolyn R. Abrigo, Jill M. Li, John Jeffrey S. Salud, Charissa Mia D. Venzon, Roy P. Lopez, Alfredo M. Jr Rodriguez, Alexander Gerald M. Veracion, Julius L. Hipolito, Mary Grace P. Pacioles, Carol Marjorie H. Tomas, Angelica Cecilia V. Embuido, Roderick R. Pavilion, Gilbert Tamondong, Manuel R. Jr Dela Cruz, Kin I. text monographic eng

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The effect of positive pressure ventilation on dynamic lung compliance, airway resistance and hemodynamics at four different tidal volumes were determined in this experiment. Six healthy, anesthesized mongrel dogs were ventilated with the Pulmo-2 Volume Cycled Mechanical Ventilator on Assist Control Mode. Each dog received the four levels of treatment (i.e., 10, 15, 20, 25 ml/kg-body weight of tidal volume) in random order. Ventilation for each tidal volume lasted for 15 minutes, after which a final measurement of the intrapleural pressure, peak airway pressure, pulmonary capillary wedge pressure and heart rate were taken. Dynamic lung compliance and airway resistance were calculated from data collected. Results of the experiment showed increased lung compliance and decreased airway resistance at higher tidal volumes. Mean arterial pressure was stable, pulmonary arterial pressure and pulmonary capillary wedge pressure decreased, while heart rate increased. Abnormal breathing patterns observe wherein spontaneous breathing alternated with positive pressure breathing indicate poor sensitivity of the ventilator. Cherie C. Ocampo [and twenty four others] Acta Medica Philippina,1997 33 ( 3 ) pages 111-119 Ventilators, Mechanical Hemodynamics Tidal Volume 210312 20210312162810.0 D0001J000163