01780nam a22001817a 4500001001300000003000400013005001700017008004100034245011800075520118000193580006101373650002401434650002101458653002501479653003201504700003901536700002301575D0001J000560DOH20210428145349.0210428b           ||||| |||| 00| 0 eng d00aMetastatic mammary carcinoma in a mature singleton placenta /cFrancia Victoria A. De Los Reyes, Arlene L. Santos3 aIntroduction Placental metastasis from maternal malignancies is a rare occurrence with a significantly adverse prognosis on the mother with no known effect or established risk factors for the newborn. As such, characterization of these lesions is necessary to serve as a stepping stone for more exhaustive studies regarding this presentation.

Case Summary This is a case of a metastatic breast carcinoma in a mature singleton placenta in a 39 year old woman diagnosed with invasive breast carcinoma of no special type/invasive ductal carcinoma, not otherwise specified, during the second trimester of pregnancy. Also discussed are the immunohistochemistry studies done to confirm the origin of the tumor. A comparison of the ER, PR, and HER2/neu receptor status between the primary lesion and the placental metastasis was also done.

Conclusion Pregnancy-associated breast cancer is a lesion that carries adverse prognosis for the because of the delay in diagnosis attributable to confusion of symptomatology. The pertinent problem in pregnancy-associated breast cancer with placental metastasis is the deficiency of the placenta to induce tumor metastasis away from itself.  a

UERM Health Science Journal, 2017   6 (1) pages  38-44 2aNeoplasm Metastasis 2aBreast Neoplasms  aPlacental Metastasis  aMetastatic Breast Carcinoma1 aDe Los Reyes, Francia Victoria A. 1 aSantos, Arlene L.