De Los Reyes, Francia Victoria A. Santos, Arlene L. text monographic eng

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Introduction Placental metastasis from maternal malignancies is a rare occurrence with a significantly adverse prognosis on the mother with no known effect or established risk factors for the newborn. As such, characterization of these lesions is necessary to serve as a stepping stone for more exhaustive studies regarding this presentation. Case Summary This is a case of a metastatic breast carcinoma in a mature singleton placenta in a 39 year old woman diagnosed with invasive breast carcinoma of no special type/invasive ductal carcinoma, not otherwise specified, during the second trimester of pregnancy. Also discussed are the immunohistochemistry studies done to confirm the origin of the tumor. A comparison of the ER, PR, and HER2/neu receptor status between the primary lesion and the placental metastasis was also done. Conclusion Pregnancy-associated breast cancer is a lesion that carries adverse prognosis for the because of the delay in diagnosis attributable to confusion of symptomatology. The pertinent problem in pregnancy-associated breast cancer with placental metastasis is the deficiency of the placenta to induce tumor metastasis away from itself. Francia Victoria A. De Los Reyes, Arlene L. Santos UERM Health Science Journal, 2017 6 (1) pages 38-44 Neoplasm Metastasis Breast Neoplasms Placental Metastasis Metastatic Breast Carcinoma 210428 20210428145349.0 D0001J000560