TY  - BOOK
AU  - Padilla,MaDominga B.
AU  - Javellana,Juan Antonio G.
AU  - Valero,Sherman O.
TI  - The effect of clotrimazole 1% solution (Canesten) on the rate of corneal epithelial wound healing in rabbit eyes
KW  - Corneal Injuries
KW  - Wound Healing
KW  - Clotrimazole
KW  - administration and dosage
KW  - Antifungal Agents
KW  - therapeutic use
N2  - We tested the effect of commercially prepared Clotrimazole 1% solution on the rate of closure of a standard 7 mm diameter corneal epithelial defect over a period of seven days and compared this to Natamycin 5% Suspension, 1% Amphotericin B Solution and placebo. The rate of closure in the Clotrimazole treated eyes was slightly slower than that of Natamycin and saline treated groups but did not significantly differ by the end of the study. Rate of wound closure was significantly slower in the Amphotericin treated eyes as compared to the Clotrimazole and the other treatment groups throughout the entire duration of the study. These findings, along with its known effectively and wide availability should push us to explore the potential of commercially prepared Clotrimazole 1% Solution as a viable alternative in the management of fungal keratitis
ER  -