02362nam a22003257a 4500 645 645 DOH 20200806155501.0 200521b ph ||||| |||| 00| 0 eng d DOH DOH A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in the Philippines / Mari Rose Aplasca de los Reyes [ and eight others] From 1994 through 1996-1997, high-level ciprofloxacin resistance (minimum inhibitory concentration [MIC], > or = 4.0 microg/mL) increased from 9% to 49% of gonococcal isolates recovered from consecutive female sex workers in Cebu and Manila, The Philippines (P < .01). During 1996-1997, 105 female sex workers with gonorrhea were prospectively randomized to receive treatment with oral ciprofloxacin, 500 mg, or cefixime, 400 mg, and followed for test of cure. Neisseria gonorrhoeae was reisolated within 28 days after treatment from 1 (3.8%) of 26 women given cefixime versus 24 (32.3%) of 72 women given ciprofloxacin (P < .01). Treatment failure (reisolation of pretreatment auxotype/serovar) occurred in 14 (46.7%) of 30 women infected with strains with MICs of ciprofloxacin > or = 4.0 microg/mL versus 1 (3.6%) of 28 infected by strains with MICs < 4.0 microg/mL (P < .01). High-level, clinically significant gonococcal resistance to ciprofloxacin has rapidly emerged in The Philippines, and spread of fluoroquinolone resistance through commercial sex poses a threat to control of gonorrhea and prevention of human immunodeficiency virus infection and the acquired immunodeficiency syndrome. In: Clinical Infectious Disease, 2001 vol. 32 (1) pages 1313-1318 Cefixime therapeutic use Ciprofloxacin therapeutic use Drug Resistance, Microbial Gonorrhea drug therapy Comparative Study Clinical Trial de los Reyes, Mari Rose Aplasca Mesola, Virginia Pato Klausner, Jeffrey D. Manalastas, Ricardo Wi, Teodora Tuazon, Carmelita U. Dallabetta, Gina Whittington, W. L. H. Holmes, King K. https://academic.oup.com/cid/article/32/9/1313/291220 JA