TY  - BOOK
AU  - Carlos,Celia C.
AU  - Inobaya,Marianette T.
AU  - Bresee,Joseph S.
AU  -  Lagrada,Marietta L.
AU  - Olorosa,Agnettah M.
AU  - Kirkwood,Carl D.
AU  - Widdowson,Marc-Alain
TI  - The burden of hospitalizations and clinic visits for rotavirus disease in children aged <5 years in the Philippines
KW  - Child, Preschool
KW  - Cost of Illness
KW  -  Gastroenteritis
KW  - epidemiology
KW  - Rotavirus
KW  - classification
KW  - Rotavirus Infections
KW  - virology
N2  - Background: Recent data on the burden of hospitalization and clinic visits for rotavirus gastroenteritis are needed to support the decision to introduce rotavirus vaccine in the Philippines.

Methods: From 2005 through 2006, children aged <5 years with acute diarrhea who attended 1 of 7 clinics and/or hospitals in Muntinlupa City, the Philippines, were enrolled. Clinical and demographic data were collected, and a stool specimen was obtained for rotavirus testing and typing for G and P antigens. The incidences of different clinical outcomes of rotavirus gastroenteritis were determined for 3 townships under surveillance and were extrapolated to the Philippines with use of national data sets.

Results: The prevalence of rotavirus was 31% (171/560) among children hospitalized with diarrhea, 30% (155/520) among those who presented to the emergency department, and 15% (56/385) among those who presented to a clinic. The annual estimated incidence (per 100,000 children aged <5 years) of rotavirus gastroenteritis in outpatient, emergency department, and inpatient settings was 755, 451, and 279, respectively. Of 274 strains, 50 (18%) were nontypeable. Of the 128 strains that underwent G and P typing, 98% belong to the globally common strains G3P[P], G2P[4], and G1P[8].

Conclusions: The burden of rotavirus gastroenteritis in the Philippines is high and is predominantly caused by strains against which current vaccines have shown good efficacy, suggesting that routine immunization will have a large impact on rotavirus disease burden
UR  - https://academic.oup.com/jid/article/200/Supplement_1/S174/848665
ER  -