02494nam a22002897a 4500999001300000001001300013003000400026005001700030008004100047040000800088245015800096520155200254650002101806650002001827650003501847650003001882650003601912700002101948700002801969700002301997700002602020700002602046700002302072700002702095856007002122942001202192  c770d770D0001E000034DOH20200806155505.0200526b        ph ||||| |||| 00| 0 eng d  cDOH04aThe burden of hospitalizations and clinic visits for rotavirus disease in children aged <5 years in the Philippines /cCelia C. Carlos [and seven others]3 aBackground: Recent data on the burden of hospitalization and clinic visits for rotavirus gastroenteritis are needed to support the decision to introduce rotavirus vaccine in the Philippines.

Methods: From 2005 through 2006, children aged <5 years with acute diarrhea who attended 1 of 7 clinics and/or hospitals in Muntinlupa City, the Philippines, were enrolled. Clinical and demographic data were collected, and a stool specimen was obtained for rotavirus testing and typing for G and P antigens. The incidences of different clinical outcomes of rotavirus gastroenteritis were determined for 3 townships under surveillance and were extrapolated to the Philippines with use of national data sets.

Results: The prevalence of rotavirus was 31% (171/560) among children hospitalized with diarrhea, 30% (155/520) among those who presented to the emergency department, and 15% (56/385) among those who presented to a clinic. The annual estimated incidence (per 100,000 children aged <5 years) of rotavirus gastroenteritis in outpatient, emergency department, and inpatient settings was 755, 451, and 279, respectively. Of 274 strains, 50 (18%) were nontypeable. Of the 128 strains that underwent G and P typing, 98% belong to the globally common strains G3P[P], G2P[4], and G1P[8].

Conclusions: The burden of rotavirus gastroenteritis in the Philippines is high and is predominantly caused by strains against which current vaccines have shown good efficacy, suggesting that routine immunization will have a large impact on rotavirus disease burden. 2aChild, Preschool 2aCost of Illness 2a Gastroenteritisxepidemiology 2aRotavirusxclassification 2aRotavirus Infections xvirology1 aCarlos, Celia C.1 aInobaya, Marianette T. 1 aBresee, Joseph S. 1 a Lagrada, Marietta L.1 aOlorosa, Agnettah M. 1 aKirkwood, Carl D. 1 aWiddowson, Marc-Alain   uhttps://academic.oup.com/jid/article/200/Supplement_1/S174/848665  cJA2nlm