000			01655nam a2200229 4500
001			D0001E000124
003			DOH
005			20201029140659.0
008			201029b ||||| |||| 00| 0 eng d
245	0	0	_aProthrombin time prolongation in paracetamol poisoning : _ba relevant marker of hepatic failure? / _cC. Payen [and three others]
520	3		_aThe association between paracetamol overdose and prolonged prothrombin time due to hepatic failure is well recognized. However, little is known of the possibility that paracetamol overdose can prolong the prothrombin time without overt hepatic failure. The few data from the literature suggest this is either due to a reduction in the functional levels of the vitamin K-dependent clotting factors by elevated doses of paracetamol, or a consequence of the administration of the antidote N-acetylcystein. The three reported cases provide further evidence that paracetamol overdose can be associated with a prolongation in the prothrombin time without overt hepatic failure. Even though the prothrombin time provides useful prognosis information, decisions regarding the management of these patients should not solely be based on this endpoint to avoid misinterpretation of the accuracy and the severity of liver failure.
580			_aIn: Human & Experimental Toxicology 2003 vol. 22 (11) pages 617-621.
650	0	2	_aAcetaminophen _xpoisoning
650	0	2	_aAnalgesics, Non-Narcotic _xpoisoning
650	0	2	_aDrug Overdose _xdiagnosis
650	0	2	_aLiver Failure _xchemically induced
700	1		_aPayen, C.
700	1		_aDachraoui, A.
700	1		_aPulce, C.
700	1		_aDescotes, J.
942			_cJA
999			_c1634 _d1634