| 000 | 02280nam a22002177a 4500 | ||
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| 001 | D0001C000056 | ||
| 003 | DOH | ||
| 005 | 20201121114613.0 | ||
| 008 | 201121b ||||| |||| 00| 0 eng d | ||
| 245 | 0 | 0 |
_aSevere acute respiratory syndrome coronavirus spike protein counteracts BST2‐mediated restriction of virus‐like particle release / _cShiu‐Mei Wang [and two others] |
| 520 | 3 | _aBST2/tetherin, an interferon-inducible antiviral factor, can block the cellular release of various enveloped viruses. We previously reported that human coronavirus 229E (HCoV-229E) infection can alleviate the BST2 tethering of HIV-1 virions by downregulating cell surface BST2, suggesting that coronaviruses are capable of encoding anti-BST2 factors. Here we report our new finding that severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) glycoprotein, similar to Vpu, is capable of antagonizing the BST2 tethering of SARS-CoV, HCoV-229E, and HIV-1 virus-like particles via BST2 downregulation. However, unlike Vpu (which downmodulates BST2 by means of proteasomal and lysosomal degradation pathways), BST2 downregulation is apparently mediated by SARS-CoV S through the lysosomal degradation pathway only. We found that SARS-CoV S colocalized with both BST2 and reduced cell surface BST2, suggesting an association between SARS-CoV S and BST2 that targets the lysosomal degradation pathway. According to one recent report, SARS-CoV ORF7a antagonizes BST2 by interfering with BST2 glycosylation1 . Our data provide support for the proposal that SARS-CoV and other enveloped viruses are capable of evolving supplementary anti-BST2 factors in a manner that requires virus replication. Further experiments are required to determine whether the BST2-mediated restriction of authentic SARS-CoV virions is alleviated by the SARS-CoV spike protein. | |
| 580 | _aIn: J Med Virol. 2019 vol. 91 (10) page: 1743–1750. Published online 2019 Jul 10. doi: 10.1002/jmv.25518 | ||
| 650 | 2 |
_a SARS Virus _xclassification |
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| 650 | 2 |
_aSARS Virus _xgenetics |
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| 650 | 2 |
_aSARS Virus _xmetabolism |
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| 700 | 1 | _aWang, Shiu‐Mei | |
| 700 | 1 | _aHuang, Kuo‐Jung | |
| 700 | 1 | _aWangcorres, Chin‐Tien | |
| 856 | _uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166632/ | ||
| 942 | _cCV | ||
| 999 |
_c1789 _d1789 |
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