000			02997nam a22003857a 4500
001			D0001C000063
003			DOH
005			20201123114606.0
008			201123b ||||| |||| 00| 0 eng d
245	0	0	_aA case study evaluating the risk of infection from Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) in a hospital setting through bioaerosols / _cUmesh Adhikari [and eleven others]
520	3		_aMiddle Eastern respiratory syndrome, an emerging viral infection with a global case fatality rate of 35.5%, caused major outbreaks first in 2012 and 2015, though new cases are continuously reported around the world. Transmission is believed to mainly occur in healthcare settings through aerosolized particles. This study uses Quantitative Microbial Risk Assessment to develop a generalizable model that can assist with interpreting reported outbreak data or predict risk of infection with or without the recommended strategies. The exposure scenario includes a single index patient emitting virus-containing aerosols into the air by coughing, leading to short- and long-range airborne exposures for other patients in the same room, nurses, healthcare workers, and family visitors. Aerosol transport modeling was coupled with Monte Carlo simulation to evaluate the risk of MERS illness for the exposed population. Results from a typical scenario show the daily mean risk of infection to be the highest for the nurses and healthcare workers (8.49 × 10-4 and 7.91 × 10-4 , respectively), and the lowest for family visitors and patients staying in the same room (3.12 × 10-4 and 1.29 × 10-4 , respectively). Sensitivity analysis indicates that more than 90% of the uncertainty in the risk characterization is due to the viral concentration in saliva. Assessment of risk interventions showed that respiratory masks were found to have a greater effect in reducing the risks for all the groups evaluated (>90% risk reduction), while increasing the air exchange was effective for the other patients in the same room only (up to 58% risk reduction).
580			_aIn: Risk Analysis 2019 vol. 39 (12) pages: 2608-2624. doi: 10.1111/risa.13389. Epub 2019 Sep 16.
650		2	_aAerosols
650		2	_aAir Microbiology
650		2	_aCoronavirus Infections _xepidemiology
650		2	_aCoronavirus Infections _xtransmission
650		2	_aCross Infection _x prevention and control
650		2	_aMasks
650		2	_aMiddle East Respiratory Syndrome Coronavirus
650		2	_aRisk Management
700	1		_aAdhikari, Umesh
700	1		_aChabrelie, Alexandre
700	1		_aWeir, Mark
700	1		_aBoehnke, Kevin
700	1		_aMcKenzie, Erica
700	1		_aIkner, Luisa
700	1		_aWang, Meng
700	1		_aWang, Qing
700	1		_aYoung, Kyana
700	1		_aHaas, Charles N
700	1		_aRose, Joan
700	1		_aMitchell, Jade
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169172/pdf/RISA-39-2608.pdf
942			_cCV
999			_c1796 _d1796