| 000 | 02378nam a22002057a 4500 | ||
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| 001 | D0001E000158 | ||
| 003 | DOH | ||
| 005 | 20201127105647.0 | ||
| 008 | 201127b ||||| |||| 00| 0 eng d | ||
| 245 | 0 | 0 |
_aCorrelation study between erythrocyte acetylcholinesterase activity, serum malondialdehyde and insulin sensitivity in agricultural workers and non-agricultural workers in Nat-Kan Village, Magway Township / _cMya Pwint Phyu [and four others] |
| 520 | 3 | _aObjective. This study determined the correlation between erythrocyte acetylcholinesterase (AChE) activity, serum malondialdehyde (MDA) and insulin sensitivity in agricultural workers and non-agricultural workers. Methodology. The cross-sectional comparative study was undertaken in 45 agricultural and 45 non-agricultural workers from Nat-Kan Village, Magway Township. Erythrocyte acetylcholinesterase activity and serum malondialdehyde were measured by spectrophotometric method. Insulin sensitivity was calculated by homeostasis model assessment (HOMA-IR). Results. Mean erythrocyte AChE activity was significantly lower in agricultural (3553.99 IU/L) compared with nonagricultural workers (4432.68 IU/L) (p<0.001). A significant high level of mean serum MDA was observed in agricultural workers (0.74 versus 0.28 μmol/L, p<0.001). Median HOMA-IR value was significantly higher in agricultural (2.74) than that of non-agricultural workers (2.28) (p<0.05). The risk of insulin resistance was 2.8 times greater in agricultural workers than non-agricultural workers (OR 2.8, 95% CI, 1.18 to 6.72). Erythrocyte AChE activity had weak negative correlation with serum MDA level (r=-0.357, p<0.001) and HOMA-IR (ρ= 0.305, p<0.05). There was a significant but weak positive correlation between serum MDA level and HOMA-IR (ρ=0.355, p<0.001). Conclusion. Organophosphate pesticide exposure lowered erythrocyte AChE activity and increased oxidative stress. Oxidative stress is partly attributed to the development of insulin resistance. | |
| 580 | _aIn: Journal of the ASEAN Federation of Endocrine Societies, 2020 Vol. 35 (1) pages: 85-92 | ||
| 700 | 1 | _aPhyu, Mya Pwint | |
| 700 | 1 | _aHlain, Zarchi Theint Theint | |
| 700 | 1 | _aZaw, Thurein | |
| 700 | 1 | _aHtway, Soe Minn | |
| 700 | 1 | _aSein, Mya Thanda | |
| 856 | _uhttps://asean-endocrinejournal.org/index.php/JAFES/article/view/645/1289 | ||
| 942 | _cJA | ||
| 999 |
_c1870 _d1870 |
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