| 000 | 02362nam a22003257a 4500 | ||
|---|---|---|---|
| 999 |
_c645 _d645 |
||
| 003 | DOH | ||
| 005 | 20200806155501.0 | ||
| 008 | 200521b ph ||||| |||| 00| 0 eng d | ||
| 040 |
_aDOH _cDOH |
||
| 245 | 2 |
_aA randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in the Philippines / _cMari Rose Aplasca de los Reyes [ and eight others] |
|
| 520 | 3 | _aFrom 1994 through 1996-1997, high-level ciprofloxacin resistance (minimum inhibitory concentration [MIC], > or = 4.0 microg/mL) increased from 9% to 49% of gonococcal isolates recovered from consecutive female sex workers in Cebu and Manila, The Philippines (P < .01). During 1996-1997, 105 female sex workers with gonorrhea were prospectively randomized to receive treatment with oral ciprofloxacin, 500 mg, or cefixime, 400 mg, and followed for test of cure. Neisseria gonorrhoeae was reisolated within 28 days after treatment from 1 (3.8%) of 26 women given cefixime versus 24 (32.3%) of 72 women given ciprofloxacin (P < .01). Treatment failure (reisolation of pretreatment auxotype/serovar) occurred in 14 (46.7%) of 30 women infected with strains with MICs of ciprofloxacin > or = 4.0 microg/mL versus 1 (3.6%) of 28 infected by strains with MICs < 4.0 microg/mL (P < .01). High-level, clinically significant gonococcal resistance to ciprofloxacin has rapidly emerged in The Philippines, and spread of fluoroquinolone resistance through commercial sex poses a threat to control of gonorrhea and prevention of human immunodeficiency virus infection and the acquired immunodeficiency syndrome. | |
| 580 | _aIn: Clinical Infectious Disease, 2001 vol. 32 (1) pages 1313-1318 | ||
| 650 |
_a Cefixime _xtherapeutic use |
||
| 650 |
_aCiprofloxacin _xtherapeutic use |
||
| 650 | _aDrug Resistance, Microbial | ||
| 650 |
_aGonorrhea _xdrug therapy |
||
| 650 | _aComparative Study | ||
| 653 | _aClinical Trial | ||
| 700 | 1 | _ade los Reyes, Mari Rose Aplasca | |
| 700 | 1 | _aMesola, Virginia Pato | |
| 700 | 1 | _aKlausner, Jeffrey D. | |
| 700 | 1 | _aManalastas, Ricardo | |
| 700 | 1 | _a Wi, Teodora | |
| 700 | 1 | _aTuazon, Carmelita U. | |
| 700 | 1 | _aDallabetta, Gina | |
| 700 | 1 | _aWhittington, W. L. H. | |
| 700 | 1 | _aHolmes, King K. | |
| 856 | _uhttps://academic.oup.com/cid/article/32/9/1313/291220 | ||
| 942 | _cJA | ||