Effects of increasing tidal volume during positive pressure ventilation on lung mechanics and hemodynamics / Cherie C. Ocampo [and twenty four others]
Subject(s): Abstract: The effect of positive pressure ventilation on dynamic lung compliance, airway resistance and hemodynamics at four different tidal volumes were determined in this experiment. Six healthy, anesthesized mongrel dogs were ventilated with the Pulmo-2 Volume Cycled Mechanical Ventilator on Assist Control Mode. Each dog received the four levels of treatment (i.e., 10, 15, 20, 25 ml/kg-body weight of tidal volume) in random order. Ventilation for each tidal volume lasted for 15 minutes, after which a final measurement of the intrapleural pressure, peak airway pressure, pulmonary capillary wedge pressure and heart rate were taken. Dynamic lung compliance and airway resistance were calculated from data collected. Results of the experiment showed increased lung compliance and decreased airway resistance at higher tidal volumes. Mean arterial pressure was stable, pulmonary arterial pressure and pulmonary capillary wedge pressure decreased, while heart rate increased. Abnormal breathing patterns observe wherein spontaneous breathing alternated with positive pressure breathing indicate poor sensitivity of the ventilator.| Cover image | Item type | Current library | Home library | Collection | Shelving location | Call number | Materials specified | Vol info | URL | Copy number | Status | Notes | Date due | Barcode | Item holds | Item hold queue priority | Course reserves | |
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Journal Article
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DOH Central Library Electronic Resource Section | J000163 (Browse shelf(Opens below)) | Available | D0001J000163 |
The effect of positive pressure ventilation on dynamic lung compliance, airway resistance and hemodynamics at four different tidal volumes were determined in this experiment. Six healthy, anesthesized mongrel dogs were ventilated with the Pulmo-2 Volume Cycled Mechanical Ventilator on Assist Control Mode. Each dog received the four levels of treatment (i.e., 10, 15, 20, 25 ml/kg-body weight of tidal volume) in random order. Ventilation for each tidal volume lasted for 15 minutes, after which a final measurement of the intrapleural pressure, peak airway pressure, pulmonary capillary wedge pressure and heart rate were taken. Dynamic lung compliance and airway resistance were calculated from data collected. Results of the experiment showed increased lung compliance and decreased airway resistance at higher tidal volumes. Mean arterial pressure was stable, pulmonary arterial pressure and pulmonary capillary wedge pressure decreased, while heart rate increased. Abnormal breathing patterns observe wherein spontaneous breathing alternated with positive pressure breathing indicate poor sensitivity of the ventilator.
Acta Medica Philippina,1997 33 ( 3 ) pages 111-119
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