Prothrombin time prolongation in paracetamol poisoning : (Record no. 1634)

MARC details
000 -LEADER
fixed length control field 01655nam a2200229 4500
003 - CONTROL NUMBER IDENTIFIER
control field DOH
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20201029140659.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 201029b ||||| |||| 00| 0 eng d
245 00 - TITLE STATEMENT
Title Prothrombin time prolongation in paracetamol poisoning :
Remainder of title a relevant marker of hepatic failure? /
Statement of responsibility, etc. C. Payen [and three others]
520 3# - SUMMARY, ETC.
Summary, etc. The association between paracetamol overdose and prolonged prothrombin time due to hepatic failure is well recognized. However, little is known of the possibility that paracetamol overdose can prolong the prothrombin time without overt hepatic failure. The few data from the literature suggest this is either due to a reduction in the functional levels of the vitamin K-dependent clotting factors by elevated doses of paracetamol, or a consequence of the administration of the antidote N-acetylcystein. The three reported cases provide further evidence that paracetamol overdose can be associated with a prolongation in the prothrombin time without overt hepatic failure. Even though the prothrombin time provides useful prognosis information, decisions regarding the management of these patients should not solely be based on this endpoint to avoid misinterpretation of the accuracy and the severity of liver failure.
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note In: Human & Experimental Toxicology 2003 vol. 22 (11) pages 617-621.
650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Acetaminophen
General subdivision poisoning
650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Analgesics, Non-Narcotic
General subdivision poisoning
650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Drug Overdose
General subdivision diagnosis
650 02 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Liver Failure
General subdivision chemically induced
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Payen, C.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Dachraoui, A.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Pulce, C.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Descotes, J.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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-- 1634
-- 1634
Holdings
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        DOH Central Library DOH Central Library Electronic Resource Section 10/29/2020   E000124 D0001E000124 10/29/2020 10/29/2020 Journal Article