Pathogenesis of Middle East respiratory syndrome coronavirus / (Record no. 1791)

MARC details
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control field DOH
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control field 20201121152257.0
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Title Pathogenesis of Middle East respiratory syndrome coronavirus /
Statement of responsibility, etc. Judith MA van den Brand [and two others]
520 3# - SUMMARY, ETC.
Summary, etc. Human coronaviruses (CoVs) mostly cause a common cold that is mild and self-limiting. Zoonotic transmission of CoVs such as the recently identified Middle East respiratory syndrome (MERS)-CoV and severe acute respiratory syndrome (SARS)-CoV, on the other hand, may be associated with severe lower respiratory tract infection. This article reviews the clinical and pathological data available on MERS and compares it to SARS. Most importantly, chest radiographs and imaging results of patients with MERS show features that resemble the findings of organizing pneumonia, different from the lesions in SARS patients, which show fibrocellular intra-alveolar organization with a bronchiolitis obliterans organizing pneumonia-like pattern. These findings are in line with differences in the induction of cytopathological changes, induction of host gene responses and sensitivity to the antiviral effect of interferons in vitro when comparing both MERS-CoV and SARS-CoV. The challenge will be to translate these findings into an integrated picture of MERS pathogenesis in humans and to develop intervention strategies that will eventually allow the effective control of this newly emerging infectious disease.
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Linking entry complexity note In: J Pathol. 2015 Jan; 235 (2): 175–184.<br/>Published online 2014 Dec 11. doi: 10.1002/path.4458
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronavirus Infections
General subdivision drug therapy
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronavirus Infections
General subdivision virology*
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronavirus Infections
General subdivision transmission
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Middle East Respiratory Syndrome Coronavirus
General subdivision drug effects
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Middle East Respiratory Syndrome Coronavirus
General subdivision isolation and purification
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Middle East Respiratory Syndrome Coronavirus
General subdivision pathogenicity
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Brand, Judith MA van den
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Personal name Smits, Saskia L
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Haagmans, Bart L
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Uniform Resource Identifier <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167882/pdf/PATH-235-175.pdf">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167882/pdf/PATH-235-175.pdf</a>
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Koha item type Journal Article
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-- 1791
-- 1791
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        DOH Central Library DOH Central Library Electronic Resource Section 11/21/2020   COVID-19-000058 D0001C000058 11/21/2020 11/21/2020 Journal Article