Risk factors and outcomes of hospitalized patients with severe COVID-19 and secondary bloodstream infections : (Record no. 1853)

MARC details
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fixed length control field 02810nam a22003377a 4500
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control field DOH
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control field 20201126135901.0
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Title Risk factors and outcomes of hospitalized patients with severe COVID-19 and secondary bloodstream infections :
Remainder of title a multicenter, case-control study /
Statement of responsibility, etc. Pinki J. Bhatt [and eleven others]
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General note Accepted manuscript.
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Summary, etc. BACKGROUND: Coronavirus disease 2019 (COVID-19) has become a global pandemic. Clinical characteristics regarding secondary infections in patients with COVID-19 have been reported but detailed microbiology, risk factors and outcomes of secondary bloodstream infections (sBSI) in patients with severe COVID-19 have not been well described. METHODS: We performed a multicenter, case-control study including all hospitalized patients diagnosed with severe COVID-19 and blood cultures drawn from March 1, 2020 to May 7, 2020 at three academic medical centers in New Jersey, USA. Data collection included demographics, clinical and microbiologic variables, and patient outcomes. Risk factors and outcomes were compared between cases (sBSI) and controls (no sBSI). RESULTS: A total of 375 hospitalized patients were included. There were 128 sBSIs during the hospitalization. For the first set of positive blood cultures, 117 (91.4%) were bacterial and 7 (5.5%) were fungal. Those with sBSI were more likely to have altered mental status, lower mean percent oxygen saturation on room air, have septic shock and be admitted to the intensive care unit compared to the controls. In-hospital mortality was higher in those with a sBSI versus controls (53.1% vs 32.8%, p=0.0001). CONCLUSIONS: We observed hospitalized adult patients with severe COVID-19 and sBSI had a more severe initial presentation, prolonged hospital course, and worse clinical outcomes. To maintain antimicrobial stewardship principles, further prospective studies are necessary to better characterize risk factors and prediction modeling to better understand when to suspect and empirically treat for sBSI in severe COVID-19.
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Linking entry complexity note In: Clinical Infectious Diseases, ciaa1748, <br/>https://doi.org/10.1093/cid/ciaa1748
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Topical term or geographic name entry element Coronavirus Infections
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Uncontrolled term Bloodstream Infections
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Uncontrolled term COVID-19
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Personal name Bhatt, Pinki J.
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Personal name Shiau, Stephanie
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Personal name Brunetti, Luigi
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Personal name iXie, Yingda
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Personal name Solanki, Kinjal
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Personal name Khalid, Shaza
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Personal name Mohayya, Sana
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Personal name Au, Pak Ho
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Personal name Pham, Christopher
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Personal name Uprety, Priyanka
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Personal name Nahass, Ronald
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Personal name Narayanan, Navaneeth
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Uniform Resource Identifier <a href="https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1748/5995838">https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1748/5995838</a>
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Koha item type COVID 19 Resource
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-- 1853
-- 1853
Holdings
Withdrawn status Lost status Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
        DOH Central Library DOH Central Library Electronic Resource Section 11/26/2020   COVID-19-000078 D0001C000078 11/26/2020 11/26/2020 COVID 19 Resource