Glucose-6-phosphate dehydrogenase deficiency in Filipino neonates with jaundice / (Record no. 3113)

MARC details
000 -LEADER
fixed length control field 02502nam a22002177a 4500
003 - CONTROL NUMBER IDENTIFIER
control field DOH
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20210227131605.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210227b ||||| |||| 00| 0 eng d
245 00 - TITLE STATEMENT
Title Glucose-6-phosphate dehydrogenase deficiency in Filipino neonates with jaundice /
Statement of responsibility, etc. Catherine Lynn T. Silao [and three others]
520 3# - SUMMARY, ETC.
Summary, etc. OBJECTIVES: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common of all clinically significant enzyme defects of red blood cells. It has a high rate of prevalence in the Philippines. Concern about hemolytic anemia and jaundice due to unrecognized G6PD deficiency led us to determine the prevalence of G6PD deficiency among jaundiced neonates in the Philippine General Hospital, a tertiary referral hospital in the Philippines. It was hypothesized that G6PD deficiency was more prevalent in neonates with jaundice than in the normal population. We also compared the clinical presentation and course (hospital stay and days of phototherapy requirement) for G6PD deficient and G6PD normal neonates.<br/><br/><br/>MATERIALS AND METHODS: We studied 102 clinically jaundiced neonates admitted to the nursery of the Philippine General Hospital. Blood samples in individual microtainers were quantitatively tested for G6PD activity using a commercial G6PD assay kit. The clinical presentation and hospital courses of patients were statistically compared using the t-test for single proportions.<br/><br/><br/>RESULTS: G6PD deficiency was diagnosed in 17 of 102 cases[16.7% (95% CI: 10.0 to 25.3)], which is significantly higher than the normal population (p<0.001). In all G6PD-deficient neonates, no evidence of other factors known to cause hyperbilirubinemia were detected. There was no significant difference on phototherapy requirement and length of hospitalization in G6PD- deficient and other jaundiced neonates.<br/><br/><br/>CONCLUSION: The prevalence of G6PD deficiency among jaundiced neonates was found to be higher than the normal population thus, early detection of this enzymopathy, regardless of sex, and close surveillance of the affected newborns is important in reducing the risk of severe hyperbilirubinemia.
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note In: Acta Medica Philippina, 2009 vol 43 (2) pages: 22-25
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Glucosephosphate Dehydrogenase
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Infant, Newborn
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Jaundice
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Silao, Catherine Lynn T.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name David-Padilla, Carmencita
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Uy, Esterlita V.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name delos Reyes, Ernesto R.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
999 ## -
-- 3113
-- 3113
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 02/27/2021   J000105 D0001J000105 02/27/2021 02/27/2021 Journal Article