Cost-benefit analysis of the newborn screening program of the Philippines / (Record no. 3280)

MARC details
000 -LEADER
fixed length control field 03207nam a22002297a 4500
003 - CONTROL NUMBER IDENTIFIER
control field DOH
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20210305134529.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210305b ||||| |||| 00| 0 eng d
245 00 - TITLE STATEMENT
Title Cost-benefit analysis of the newborn screening program of the Philippines /
Statement of responsibility, etc. Carmencita David-Padilla [and six others]
520 3# - SUMMARY, ETC.
Summary, etc. BACKGROUND: Newborn Screening (NBS) is a public health activity aimed at the early identification of infants who are affected by certain genetic/metabolic/infectious conditions. A cost analysis is critical for national implementation for integration as a public health program.<br/><br/><br/>OBJECTIVES: 1) To determine the incidence rates of congenital hypothyroidism (CH), congenital adrenal hyperplasia (CAH), galactosemia (GAL), phenylketonuria (PKU) and glucose-6-phosphate dehydrogenase (G6PD) deficiency; and 2) To determine whether NBS is cost-beneficial for each disorder individually or in combination, from a societal perspective.<br/><br/><br/>STUDY DESIGN: Cross sectional survey and cost-benefit analysis.<br/><br/><br/>SUBJECTS AND METHODS: The study was conducted through a screening survey of the original 24 Metro Manila hospitals. Newborns were screened for CH, CAH, GAL, PKU and G6PD deficiency after the 24th hour of life. Those who screened positive underwent serum confirmatory testing. Using incidence rates from the screening survey, a population of 1.5 million, and different screening combinations, the costs for the detection and treatment of the five disorders were compared to the benefits projected from preventing the corresponding complications and consequent productivity losses. For economic evaluation, we compared sequential analysis of doing tandem/multiple testing for the different disorders vs a "do-nothing" alternative. Sensitivity analyses for different incidence and discount rates were conducted to test the strength of the conclusions.<br/><br/><br/>RESULTS: The incidences of the disorders with 95% confidence intervals are: CH is 1:3 235 (1:2 219 - 1:5 946); CAH is 1:7 455 (1:4 046 - 1: 14245); GAL is 1: 106 006 (1: 44 218-1:266 796); and G6PD deficiency is 1:167 (1:151 - 1: 186). Screened individually, CH and G6PD deficiency had net benefits of US$ 5.29 M and US$ 15.44 M, respectively. The other conditions yielded net costs when screened individually - CAH (US$ 2.61 M), GAL (US$ 0.90 M) and PKU (US$ 6.74 M). Pairing the disorders with CH showed the following benefit:cost ratios - CH + CAH, 1.3; CH + GAL, 2.0; CH + G6PD deficiency, 3.4; and CH + PKU, 0.9. Combining disorders resulted in the following benefit:cost ratios - CH + CAH + GAL, 1.2; CH + CAH + GAL + PKU, 0.8; and CH + CAH + GAL + G6PD deficiency, 2.1. Screening for the 5 disorders in tandem resulted in a benefit:cost ratio of 1.4 and a net benefit of US$ 11.42 M.
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note In: Acta Medica Philippina, 2009 vol 43 (2) pages: 46-52
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Neonatal Screening
Geographic subdivision Philippines
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Newborn Screening
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name David-Padilla, Carmencita
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Dans, Leonila F.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Tamondong, Manuel R.
Titles and other words associated with a name Jr.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Bernal, Rose Marichelle S.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Laceste, John Joseph O.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Capistrano-Estrada, Sylvia
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
999 ## -
-- 3280
-- 3280
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 03/05/2021   J000111 D0001J000111 03/05/2021 03/05/2021 Journal Article