Screening for the activity of centella asiatica (L.) urb. on mice with induced depression / (Record no. 3459)

MARC details
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fixed length control field 03545nam a22004337a 4500
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control field DOH
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control field 20210312110613.0
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fixed length control field 210312b ||||| |||| 00| 0 eng d
245 00 - TITLE STATEMENT
Title Screening for the activity of centella asiatica (L.) urb. on mice with induced depression /
Statement of responsibility, etc. Preciosa M. Coloma [and twenty two others]
520 3# - SUMMARY, ETC.
Summary, etc. Centella asiatica (L.) Urb was screened for its activity in mice with induced depression using the Forced Swimming Test ( FST ) and the Shuttle Box Escape Test (SBET) as models of depression. Acute toxicity test using oral crude extract preparations on mice' snowed no lethality at all doses and aminimum effective dose of 6g/kgBW, based on characterization of toxidrome. For the forced swimming test, 36 mice were preconditioned by subjecting to forced swimming for 15 minutes. Twenty- four hours later, their cumulative immobility time per 5 minutes of forced swimming was taken as baseline testing, a negative group was gavaged with flouxetine ( Prozac) 10mg/kgBW, and an experimental group was gavaged with centella asiatica crude extract 6g/kgBW. One hour after gavage, the cumulative immobility time per 5 minutes forced swimming of all three groups was measured. For the Shuttle box escape test, 30 out of 43 mice were preconditioned being subjected to 60 separate electric shocks ( 15 sec, 28V per shock); the remaining 13 mice served as negative control. Forty -eight hours later, escaped after all 43 mice was taken as baseline 23 hours after baseline testing , 15 mice served as positive control and were gavaged with Fluoxetine ( prozac) 2mg/kgBW and 15 mice served as the experimental group and were gavaged with centella extract. The remaining 14 mice served as negative control. One hour fater gavage, mean escape latencies of all 43 mice were measured. For the FST, analysis of variance of mean immobility time decrease ( MITD ) of NSS-treated mice is significantly difference between the MITD of centella-treated and prosac treated mice. For the SBET, wilcoxon tests showed no significant difference in the mean escape latencies ( MEL ) of NSS-treated and centella-treated mice. T-test showed that the MEL in baseline is not significantly higher than that of centella asiatica stimulates the CNS at doses less than 100g/kgBW and depresses the CNS at higher doses. Side effects of centella include diuresis, hypersalivation and diarrhea ( not dose related ). Using the FST and SBET, centella asistica extract used at a dose of 6g/kgBW has no anti-depressant activity in mice.
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note Acta Medica Philippina, 1997 33 ( 2 ) pages 1-25
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Centella
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Depression
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Coloma, Preciosa M.
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Personal name Tan, Charissa Charlene L.
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Personal name Alfonso, Victor J. Jr.
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Personal name Buenafe, Xander H.
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Personal name Coloma, Carl Adam C.
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Personal name Lapid Jr, Ronald A.
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Personal name Leal, Dabe Roy B.
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Personal name Manloctao, Rainer L.
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Personal name Miranda, Cyndee C.
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Personal name Oliveros, Milette B.
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Personal name Oribello, Adrian M.
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Personal name Resubal, Jose Rafael E.
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Personal name Rodriguez, Cristina P.
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Personal name Romano, Rico Vincent M.
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Personal name Sabtirul, Merhamar L.
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Personal name Sales, Shelley S.
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Personal name Salvador Jr III, Marcial Q.
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Personal name Santos, Jhoana M.
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Personal name Talingdan, Marilyn C.
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Personal name Tana, Larry Q.
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Personal name Uy, Norwin T.
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Personal name Villanueva, Ma Pia B.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Yango, Charina D.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 03/12/2021   J000145 D0001J000145 03/12/2021 03/12/2021 Journal Article