Determination of serum penicillin levels using high performance liquid chromatography (HPLC) and disk diffusion method among Filipino rheumatic patients following benzathine penicillin G injection / (Record no. 3557)

MARC details
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control field DOH
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control field 20210316165944.0
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Title Determination of serum penicillin levels using high performance liquid chromatography (HPLC) and disk diffusion method among Filipino rheumatic patients following benzathine penicillin G injection /
Statement of responsibility, etc. Christine Cruz-Conducto [and four others]
520 3# - SUMMARY, ETC.
Summary, etc. Rheumatic fever (RF) and rheumatic heart disease (RHD) in the Philippines remain to be significant causes of morbidity and mortality among children. This study aimed to determine serum penicillin levels of benzathine penicillin G (BPG) in Filipino children with RF/RHD after intramuscular administration of 1.2 M units of BPG after 21 and 28 days using the high performance liquid chromatography (HPLC) and the disk diffusion (DD) assay (utilizing the minimum inhibitory concentration for penicillin). Levels were determined at the following intervals: 0,7,14,21 and 28 days after the administration of BPG. A total of 49 patients were recruited from a tertiary hosptials R.H.D. Clinic of the pediatric Out-patient department. Thirty patients were included in the DD assay and 32 in the HPLC method with 13 patients common to both methods. The serum BPG levels peaked at day 14 in the HPLC method and 7 in the DD method. With the disk diffusion method, levels were still detectable on day 28; but with the HPLC method, PBG levels were not detectable in 15.3% on day 21 an in 53.6% on day 28. These data would suggest that BPG levels in majority of cases reaches zero level before day 28. We therefore recommend that BPG be administered every 21 days.
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note Acta Medica Philippina,1997 33 ( 3 ) pages 149-156
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Penicillin G
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rheumatic Fever
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rheumatic Heart Disease
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Chromatography, High Pressure Liquid
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Cruz-Conducto, Christine
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Ortiz, Edgardo E.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Valencia, Cynthia I.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Francisco, Maria Ronella
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Chan, Veronica F.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 03/16/2021   J000167 D0001J000167 03/16/2021 03/16/2021 Journal Article