A preliminary study on the oral acute toxicity of kintsay (Apium graviolens L.) in BFAD : ICR mice (Record no. 3769)

MARC details
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fixed length control field 01754nam a22002057a 4500
003 - CONTROL NUMBER IDENTIFIER
control field DOH
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20210324163102.0
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245 00 - TITLE STATEMENT
Title A preliminary study on the oral acute toxicity of kintsay (Apium graviolens L.) in BFAD : ICR mice
Remainder of title ICR mice /
Statement of responsibility, etc. Flordeliza S. Aungon, Oscar G. Gutierrez
520 3# - SUMMARY, ETC.
Summary, etc. Kintsay (Apium graviolens L.) is know to have some diuretic and hypotensive effects in man. A preliminary study on the oral toxicity of kintsay in BFAD: ICR mice was carried out. A pure extract was prepared and orally administered to four groups of mice of each sex at the dose levels of 160, 240, 320 and 400 mg/kg body weight. The treatment resulted in one mortality for each sex from the highest dose group. The female died in 1 hour and 25 minutes post-treatment after showing signs of decrease motor activity, ataxia, head-shaking, lethargy and abdominal breathing, while the male died after 8 days without exhibiting any toxic signs and loss in body weight. Upon necropsy, the male mouse have enlarged liver and spleen. The estimated median lethal dose of kintsay in mice was more than 400 mg/kg body weight. The findings of the preliminary study in mice gave indication that kintsay at large single dose may have delayed systemic effects with deleterious consequence other than the immediate lethal toxic effect. A definitive oral acute toxicity test of kintsay is recommended in the future.(Author)
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note BFAD Laboratory Information Bulletin, 1995 1 (1) pages 5-8
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Apium
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Toxicity Tests
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Apium graviolens L
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Kintsay
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Aungon, Flordeliza S.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Gutierrez, Oscar G.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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-- 3769
-- 3769
Holdings
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 03/24/2021   J000318 D0001J000318 03/24/2021 03/24/2021 Journal Article