Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge / (Record no. 3787)

MARC details
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fixed length control field 04233nam a22008057a 4500
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control field DOH
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control field 20210326105912.0
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Title Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge /
Statement of responsibility, etc. Betty Raman [forty nine others]
520 3# - SUMMARY, ETC.
Summary, etc. Background: The medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality of life and mental health are poorly understood.<br/><br/>Methods: Fifty-eight COVID-19 patients post-hospital discharge and 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver and kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary exercise test (CPET), quality of life, cognitive and mental health assessments.<br/><br/>Findings: At 2-3 months from disease-onset, 64% of patients experienced breathlessness and 55% reported fatigue. On MRI, abnormalities were seen in lungs (60%), heart (26%), liver (10%) and kidneys (29%). Patients exhibited changes in the thalamus, posterior thalamic radiations and sagittal stratum on brain MRI and demonstrated impaired cognitive performance, specifically in the executive and visuospatial domains. Exercise tolerance (maximal oxygen consumption and ventilatory efficiency on CPET) and six-minute walk distance were significantly reduced. The extent of extra-pulmonary MRI abnormalities and exercise intolerance correlated with serum markers of inflammation and acute illness severity. Patients had a higher burden of self-reported symptoms of depression and experienced significant impairment in all domains of quality of life compared to controls (p<0.0001 to 0.044).<br/><br/>Interpretation: A significant proportion of patients discharged from hospital reported symptoms of breathlessness, fatigue, depression and had limited exercise capacity. Persistent lung and extra-pulmonary organ MRI findings are common in patients and linked to inflammation and severity of acute illness.
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Linking entry complexity note EClinicalMedicine, 2021 Jan 7;31:100683. <br/>doi: 10.1016/j.eclinm.2020.100683
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element COVID-19
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronavirus
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Magnetic Resonance Imaging
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Topical term or geographic name entry element Mental Health
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Topical term or geographic name entry element Survivors
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Multiorgan Effects
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Raman, Betty
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Personal name Cassar, Mark Philip
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Personal name Tunnicliffe, Elizabeth M.
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Personal name Filippini, Nicola
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Personal name Griffanti, Ludovica
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Personal name Alfaro-Almagro, Fidel
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Personal name Okell, Thomas
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Personal name Sheerin, Fintan
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Personal name Xie, Cheng
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Personal name Mahmod, Masliza
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Personal name Moze, Ferenc E.
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Personal name Lewandowski, Adam J.
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Personal name Ohuma, Eric O.
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Personal name Holdsworth, David
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Personal name Lamlum, Hanan
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Personal name Woodman, Myles J.
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Personal name Krasopoulos, Catherine
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Personal name Mills, Rebecca
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Personal name McConnell, Flora A. Kennedy
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Personal name Wang, Chaoyue
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Personal name Arthofer, Christoph
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Personal name Lange, Frederik J.
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Personal name Andersson, Jesper
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Personal name Jenkinson, Mark
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Personal name Antoniades, Charalambos
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Personal name Channon, Keith M.
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Personal name Shanmuganathan, Mayooran
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Personal name Ferreira, Vanessa M.
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Personal name Piechnik, Stefan K.
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Personal name Klenerman, Paul
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Personal name Brightling, Christopher
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Personal name Talbot, Nick P.
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Personal name Petousik, Nayia
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Personal name Rahman, Najib M.
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Personal name Hom, Ling-Pei
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Personal name Saunders, Kate
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Personal name Geddes, John R.
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Personal name Harrison, Paul J.
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Personal name Pattinsono, Kyle
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Personal name Rowlando, Matthew J.
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Personal name Angus, Brian J.
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Personal name Gleeson, Fergus
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Personal name Pavlides, Michael
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Personal name Koychev, Ivan
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Personal name Millerd, Karla L.
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Personal name Mackay, Clare
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Personal name Jezzar, Peter
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Personal name Smith, Stephen M.
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Personal name Neubauer, Stefan
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://www.thelancet.com/action/showPdf?pii=S2589-5370%2820%2930427-2">https://www.thelancet.com/action/showPdf?pii=S2589-5370%2820%2930427-2</a>
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type COVID 19 Resource
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-- 3787
-- 3787
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 03/26/2021   COVID-19-000162 D0001C000162 03/26/2021 03/26/2021 COVID 19 Resource