Serological evidence of human infection with SARS-CoV-2 : a systematic review and meta-analysis (Record no. 3789)

MARC details
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fixed length control field 02976nam a22003617a 4500
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control field DOH
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control field 20210326113135.0
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Title Serological evidence of human infection with SARS-CoV-2 : a systematic review and meta-analysis
Statement of responsibility, etc. Xinhua Chen [and eleven others]
520 3# - SUMMARY, ETC.
Summary, etc. Background: A rapidly increasing number of serological surveys for anti-SARS-CoV-2 antibodies have been reported worldwide. A synthesis of this large corpus of data is needed.<br/><br/>Purpose: To evaluate the quality of serological studies and provide a global picture of seroprevalence across demographic and occupational groups, and to provide guidance for conducting better serosurveys.<br/><br/>Data sources: PubMed, Embase, Web of Science, medRxiv, bioRxiv, SSRN and Wellcome were searched for English-language papers published from December 1, 2019 to August 28, 2020.<br/><br/>Study selection: Serological studies that evaluated seroprevalence of SARS-CoV-2 infections in humans.<br/><br/>Data extraction: Two investigators independently extracted data from included studies.<br/><br/>Data synthesis: Most of 178 serological studies, representing tests in >800,000 individuals, identified were of low quality. Close contacts and high-risk healthcare workers had higher seroprevalence of 22.9% (95% CI: 11.1-34.7%) and 14.9% (4.8-25.0%), compared to low-risk healthcare workers and general population of 5.5% (4.6-6.4%) and 6.3% (5.5-7.1%). Generally, young people (0-20 yrs) were less likely to be seropositive compared to the middle-aged (21-55 yrs) populations (RR, 0.8, 95% CI: 0.7-0.8). Seroprevalence correlated with clinical COVID-19 reports with 10 (range: 2 to 34) infections per confirmed COVID-19 case.<br/><br/>Limitations: Some heterogeneity cannot be well explained quantitatively.<br/><br/>Conclusions: The overall quality of seroprevalence studies examined was low. The relatively low seroprevalence among general populations suggest that in most settings, antibody-mediated herd immunity is far from being reached. Given that ratio of infections to confirmed cases is on the same order of magnitude across different locales, reported case numbers may help provide insights into the proportion of the population infected.
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Linking entry complexity note medRxiv 2020 Sep 13;2020.09.11.20192773. <br/>doi: 10.1101/2020.09.11.20192773
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Topical term or geographic name entry element COVID-19
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Topical term or geographic name entry element Serologic Tests
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronavirus Infections
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Systematic Review
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element SARS-CoV-2
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Corona Virus
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Personal name Chen, Xinhua
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Personal name Chen, Zhiyuan
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Personal name Azman, Andrew S
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Personal name Deng, Xiaowei
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Personal name Chen, Xinghui
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Personal name Lu, Wanying
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Personal name Zhao, Zeyao
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Personal name Yang, Juan
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Personal name Viboud, Cecile
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Personal name Ajelli, Marco
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Personal name Leung, Daniel T
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Personal name Yu, Hongjie
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Uniform Resource Identifier <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491537/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491537/</a>
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Koha item type COVID 19 Resource
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-- 3789
-- 3789
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 03/26/2021   COVID-19-000164 D0001C000164 03/26/2021 03/26/2021 COVID 19 Resource