Effect of trimetazidine on left ventricular ejection fraction and time to develop 1mm ST depression in patients with chronic stable Angina: A meta-analysis (Record no. 3977)

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fixed length control field 02235nam a22001697a 4500
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control field DOH
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control field 20210410145351.0
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245 00 - TITLE STATEMENT
Title Effect of trimetazidine on left ventricular ejection fraction and time to develop 1mm ST depression in patients with chronic stable Angina: A meta-analysis
Statement of responsibility, etc. Alvin V. Amoguis
520 3# - SUMMARY, ETC.
Summary, etc. Search Strategies: A systematic search was performed with the use of electronic database, including Medline PubMed, Ovid, the Cochrane Library.<br/><br/>Selection Criteria: A study was included in this meta-analysis if it was published, randomised, placebo-controlled and it reported the effect of trmetazidine with placebo on stable angina pectoris and /or myocardial ischemia.<br/><br/>Data collection and analysis: Details of the study design, patient characteristics, intervention, duration of therapy were extracted by the author. Analysis was done with the calculation of the weighted mean difference and chi-square test using standard meta-analysis software (RevMan 4,2,3) .<br/><br/>Main Results: The result of our meta-analysis showed that compared to placebo, trimetazidine significantly increases ejection fraction and time to develop 1 mm ST depression during exercise. Overall,the improvement of ejection fraction was 14.67% (CI 12.59 - 16.75). The study was relatively heterogeneous in our analysis by chi-square test. This is due to various in parameters in the included studies as previously mentioned.<br/><br/>Reviewers conclusion: The result of this meta-analysis suggest that trimetazidine is superior to placebo in increasing the ejection fraction and time to developing 1mm ST depression in patients with chronic stable angina. However, the overall quality of the included studies weakens the validity of these findings. Except for influenza-like symptoms, there are no studies demonstrating detrimental effects of trimetazidine intake. Therefore, with its other cardiovascular benefits, trimetazidine is good alternatiove to treating patients with chronic stable angina.
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Linking entry complexity note The Filipino Family Physician, 2008 46 (2) pages 78-86
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Trimetazidine
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Angina, Stable
650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Meta-Analysis
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Koha item type Journal Article
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-- 3977
-- 3977
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    National Library of Medicine     DOH Central Library DOH Central Library Electronic Resource Section 04/10/2021   J000430 D0001J000430 04/10/2021 04/10/2021 Journal Article