A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in the Philippines / (Record no. 645)

MARC details
000 -LEADER
fixed length control field 02362nam a22003257a 4500
003 - CONTROL NUMBER IDENTIFIER
control field DOH
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20200806155501.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 200521b ph ||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency DOH
Transcribing agency DOH
245 #2 - TITLE STATEMENT
Title A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in the Philippines /
Statement of responsibility, etc. Mari Rose Aplasca de los Reyes [ and eight others]
520 3# - SUMMARY, ETC.
Summary, etc. From 1994 through 1996-1997, high-level ciprofloxacin resistance (minimum inhibitory concentration [MIC], > or = 4.0 microg/mL) increased from 9% to 49% of gonococcal isolates recovered from consecutive female sex workers in Cebu and Manila, The Philippines (P < .01). During 1996-1997, 105 female sex workers with gonorrhea were prospectively randomized to receive treatment with oral ciprofloxacin, 500 mg, or cefixime, 400 mg, and followed for test of cure. Neisseria gonorrhoeae was reisolated within 28 days after treatment from 1 (3.8%) of 26 women given cefixime versus 24 (32.3%) of 72 women given ciprofloxacin (P < .01). Treatment failure (reisolation of pretreatment auxotype/serovar) occurred in 14 (46.7%) of 30 women infected with strains with MICs of ciprofloxacin > or = 4.0 microg/mL versus 1 (3.6%) of 28 infected by strains with MICs < 4.0 microg/mL (P < .01). High-level, clinically significant gonococcal resistance to ciprofloxacin has rapidly emerged in The Philippines, and spread of fluoroquinolone resistance through commercial sex poses a threat to control of gonorrhea and prevention of human immunodeficiency virus infection and the acquired immunodeficiency syndrome.
580 ## - LINKING ENTRY COMPLEXITY NOTE
Linking entry complexity note In: Clinical Infectious Disease, 2001 vol. 32 (1) pages 1313-1318
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cefixime
General subdivision therapeutic use
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Ciprofloxacin
General subdivision therapeutic use
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Drug Resistance, Microbial
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Gonorrhea
General subdivision drug therapy
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Comparative Study
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Clinical Trial
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name de los Reyes, Mari Rose Aplasca
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Mesola, Virginia Pato
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Klausner, Jeffrey D.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Manalastas, Ricardo
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Wi, Teodora
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Tuazon, Carmelita U.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Dallabetta, Gina
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Whittington, W. L. H.
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Holmes, King K.
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://academic.oup.com/cid/article/32/9/1313/291220">https://academic.oup.com/cid/article/32/9/1313/291220</a>
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article

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