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Diagnosis of tuberculous meningitis using enzyme-linked immunosorbent assay utilizing a 30,000-dalton native antigen of mycobacterium tuberculosis / Jaime C. Montoya

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Montoya, Jaime C

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Abstract: An enzyme-linked immunosorbent assay (ELISA) was estimated for the detection of lgG antibody in human cerebrospinal fluid (CSF) from patients with tuberculous meningitis to the 30,000-Da native antigen of Mycobacterium tuberculosis. The test was done on patients with bacteriologically confirmed and autopsy-proven tuberculous meningitis (8 cases), clinically presumptive cases of tuberculous neurologic disease (88 cases) and normal patients with neurologic disease (10 cases). The test was positive in 7 of the 8 cases of bacteriologically confirmed tuberculous meningitis (87.5%). ELISA was also positive in 67 of 100 cases of clinically presumptive tuberculous meningitis (67.00%). Overall sensitivity was found to be 68.51%. Specificity of ELISA was found to be 97.95% (96/98). The results show the potential use of ELISA as a rapid diagnosis test for tuberculous meningitis .

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	Journal Article	DOH Central Library Electronic Resource Section				J000159 (Browse shelf(Opens below))					Available			D0001J000159

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An enzyme-linked immunosorbent assay (ELISA) was estimated for the detection of lgG antibody in human cerebrospinal fluid (CSF) from patients with tuberculous meningitis to the 30,000-Da native antigen of Mycobacterium tuberculosis. The test was done on patients with bacteriologically confirmed and autopsy-proven tuberculous meningitis (8 cases), clinically presumptive cases of tuberculous neurologic disease (88 cases) and normal patients with neurologic disease (10 cases). The test was positive in 7 of the 8 cases of bacteriologically confirmed tuberculous meningitis (87.5%). ELISA was also positive in 67 of 100 cases of clinically presumptive tuberculous meningitis (67.00%). Overall sensitivity was found to be 68.51%. Specificity of ELISA was found to be 97.95% (96/98). The results show the potential use of ELISA as a rapid diagnosis test for tuberculous meningitis .

Acta Medica Philippina, 2000 36 ( 1&2 ) pages 22-26

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